ALEXANDRIA, Va., May 26 -- United States Patent no. 12,637,663, issued on May 26, was assigned to KM BIOLOGICS Co. LTD. (Kumamoto, Japan).
"Oncolytic vaccinia virus" was invented by Toshio Murakami (Kikuchi, Japan), Go Okita (Kikuchi, Japan) and Yui Kamizuru (Kikuchi, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is an oncolytic virus having both improved safety and productivity. Provided are: a conditionally replicating vaccinia virus which lacks the functions of a vaccinia virus growth factor (VGF), an extracellular signal-regulated kinase (ERK) activation protein, and a ribonucleotide reductase (RNR), is not replicated in a normal cell, is selectively replicable in a proliferative cell, an...