ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,741,991, issued on Sept. 22, was assigned to KATHOLIEKE UNIVERSITEIT LEUVEN (Leuven, Belgium).
"Live-attenuated flaviviruses with heterologous antigens" was invented by Robbert Boudewijns (Essen, Belgium), Kai Dallmeier (Kessel-Lo, Belgium) and Johan Neyts (Kessel-Lo, Belgium).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to polynucleotides comprising the sequence of a flavivirus preceded by a sequence encoding an N terminal part of a flavivirus Capsid protein, an immunogenic protein, or a part thereof comprising a an immunogenic peptide, and a 2A cleaving peptide, and to the virus encoded by such sequences. The invention further ...