US Patent Issued to Juno Therapeutics on Sept. 15 for "Stabilization of polyethyleneimine-deoxyribonucleic acid complex size and activity" (Washington Inventors)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,727, issued on Sept. 15, was assigned to Juno Therapeutics Inc. (Seattle).

"Stabilization of polyethyleneimine-deoxyribonucleic acid complex size and activity" was invented by Brynn Olden (Seattle), Robert Barnes (Seattle), Elizabeth Larimore (Seattle) and Julie Shi (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are methods and systems for producing polymer-DNA nanoparticles of a predetermined size. In one example, a method includes mixing together a first solution comprising deoxyribonucleic acid (DNA) with a second solution comprising a cationic polymer to obtain a polyplex solution, and at a predetermined time subsequent to mi...