ALEXANDRIA, Va., July 14 -- United States Patent no. 12,678,499, issued on July 14, was assigned to Iovance Biotherapeutics Inc. (San Carlos, Calif.).

"Treatment with tumor infiltrating lymphocyte therapies in combination with CTLA-4 and PD-1 inhibitors" was invented by Maria Fardis (San Carlos, Calif.), Friedrich-Reinhard Graf Finck von Finckenstein (San Carlos, Calif.) and Zelanna Goldberg (Redwood City, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of cancer with TILs in combination with CTLA-4 an...