US Patent Issued to Ionis Pharmaceuticals on Sept. 29 for "Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphodiester linkages" (California Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,260, issued on Sept. 29, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphodiester linkages" was invented by Andrew K. McPherson (San Diego), Andrew A. Rodriguez (San Diego) and Daniel C. Capaldi (Carlsbad, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods for synthesizing oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage. In certain embodiments, the present disclosure provides oxidation reagents that produce low amounts of unwant...