ALEXANDRIA, Va., April 7 -- United States Patent no. 12,595,482, issued on April 7, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Linkage modified oligomeric compounds and uses thereof" was invented by Brooke A. Anderson (San Diego), Xue-Hai Liang (Del Mar, Calif.), William John Drury III (Oceanside, Calif.), Michael Oestergaard (Carlsbad, Calif.), Michael T. Migawa (Carlsbad, Calif.) and Punit P. Seth (Carlsbad, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group...