US Patent Issued to Integrated DNA Technologies on Sept. 22 for "Ubiquitin variant with high affinity for binding 53BP1 reduces the amount of AAV needed to achieve high rates of HDR" (Iowa Inventors)

ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,741,995, issued on Sept. 22, was assigned to Integrated DNA Technologies Inc. (Coralville, Iowa).

"Ubiquitin variant with high affinity for binding 53BP1 reduces the amount of AAV needed to achieve high rates of HDR" was invented by Steve Ehren Glenn (North Liberty, Iowa), Michael Allen Collingwood (Solon, Iowa) and Christopher Anthony Vakulskas (North Liberty, Iowa).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention pertains to a tag-free CM1 polypeptide and methods for improving homology directed repair (HDR) in a recipient cell using the same. Preferred donor template delivery vehicles include Adeno virus-associated vectors for deli...