US Patent Issued to Integrated DNA Technologies on May 13 for "Mutations in Streptococcus pyogenes Cas9 discovered by broad scanning mutagenesis demonstrate enhancement of DNA cleavage activity" (Iowa Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,435, issued on May 13, was assigned to Integrated DNA Technologies Inc. (Coralville, Iowa).

"Mutations in Streptococcus pyogenes Cas9 discovered by broad scanning mutagenesis demonstrate enhancement of DNA cleavage activity" was invented by Nathaniel Hunter Roberts (Iowa City, Iowa), Liyang Zhang (North Liberty, Iowa) and Christopher Anthony Vakulskas (North Liberty, Iowa).

According to the abstract* released by the U.S. Patent & Trademark Office: "This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated muta...