US Patent Issued to INDENA on Sept. 2 for "Process for the purification of indole carbazole alkaloids" (Italian Inventors)

ALEXANDRIA, Va., Sept. 3 -- United States Patent no. 12,404,282, issued on Sept. 2, was assigned to INDENA S.P.A. (Milan).

"Process for the purification of indole carbazole alkaloids" was invented by Katia Miele (Milan), Luca Domenighini (Milan) and Daniele Ciceri (Milan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed is a process for the purification of staurosporine (1), which comprises salification of staurosporine (1) (Formula (1)) by treatment with a mineral acid to give a precipitated salt, isolation of the staurosporine (1) precipitated salt, treatment of the staurosporine (1) isolated salt with an organic base, and isolation of staurosporine (1). Also disclosed are novel polymorphic forms of...