US Patent Issued to Illumina on Oct. 27 for "Graph reference genome and base-calling approach using imputed haplotypes" (California Inventor)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,776,389, issued on Oct. 27, was assigned to Illumina Inc. (San Diego).

"Graph reference genome and base-calling approach using imputed haplotypes" was invented by Michael A Eberle (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to systems, non-transitory computer-readable media, and methods for generating a graph reference genome customized for a particular sample genome and utilizing the customized graph reference genome to determine final nucleotide-base calls for the sample genome. To illustrate, the disclosed systems can generate a customized graph reference genome including various paths representing imputed...