US Patent Issued to Hoffmann-La Roche on Sept. 29 for "Process for the manufacture of tetrazole derivatives" (Austrian, German, Swiss Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,217, issued on Sept. 29, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Process for the manufacture of tetrazole derivatives" was invented by Dainis Kaldre (Lorrach, Germany), Christian Oliver Kappe (Graz, Austria), Christian Steffen Moessner (Lorrach, Germany), Peter Sagmeister (Graz, Austria), Joerg Mathias Sedelmeier (Basel, Switzerland) and Jason Douglas Williams (Graz, Austria).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a process for preparing a compound of formula (I),comprising reacting a compound of formula (II)with trimethylsilyl azide (TMSN3) and a chlorinating agent in acetonitrile, wher...