US Patent Issued to Hoffmann-La Roche on Sept. 1 for "Modification of antibody FcRn binding" (German Inventors)

ALEXANDRIA, Va., Sept. 1 -- United States Patent no. 12,723,069, issued on Sept. 1, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Modification of antibody FcRn binding" was invented by Thomas Emrich (Iffeldorf, Germany), Hubert Kettenberger (Munich), Thomas Kraft (Munich), Wolfgang Richter (Lorrach, Germany) and Tilman Schlothauer (Penzberg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for providing a modified antibody with improved in vivo half-live, comprising the modification of the Fc-region of the antibody by introducing one or more mutations that change the binding of the Fc-region to human FcRn until the (relative) retention time of the modified an...