US Patent Issued to Hoffmann-La Roche on Oct. 27 for "Process for culturing mammalian cells" (German Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,448, issued on Oct. 27, was assigned to Hoffmann-La Roche Inc..

"Process for culturing mammalian cells" was invented by Katrin Greppmair (Penzberg, Germany), Thomas Link (Penzberg, Germany) and Zhixin Shao (Penzberg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Processes for culturing mammalian cells, and for producing recombinant products expressed by mammalian cells, involving a pH up-shift are provided. The processes are particularly suitable for industrial-scale cell culture, and for culture of cells that produce therapeutic products. The processes comprise a first culture stage, carried out at a first pH, and a second culture stage, c...