US Patent Issued to Hoffmann-La Roche on Nov. 11 for "Method for the generation of an FCRN expressing cell by targeted integration of multiple expression cassettes in a defined organization" (German Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,466,872, issued on Nov. 11, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Method for the generation of an FCRN expressing cell by targeted integration of multiple expression cassettes in a defined organization" was invented by Tilman Schlothauer (Penzberg, Germany), Stefan Seeber (Sindelsdorf, Germany) and Jasmin Maria Wehrstein (Ulm, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for producing C-terminally biotinylated FcRn comprising the steps of cultivating a mammalian cell comprising a deoxyribonucleic acid encoding FcRn and E. coli biotin-[acetyl-CoA-carboxylase] ligase (BirA) in a biotin containi...