ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,290, issued on May 13, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).
"Method for generating multispecific antibodies from monospecific antibodies" was invented by Ulrich Brinkmann (Penzberg, Germany), Stefan Dengl (Penzberg, Germany), Guy Georges (Penzberg, Germany), Eike Hoffmann (Penzberg, Germany), Klaus Mayer (Penzberg, Germany) and Felix Bormann (Penzberg, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for the generation of multispecific antibodies by a half-antibody exchange reaction between two 2/3-IgGs destabilized in one half by asymmetric perturbing mutations fostering the generation of co...