US Patent Issued to Hoffmann-La Roche on March 3 for "Method for generating avid-binding multispecific antibodies" (German Inventors)

ALEXANDRIA, Va., March 3 -- United States Patent no. 12,565,536, issued on March 3, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Method for generating avid-binding multispecific antibodies" was invented by Ulrich Brinkmann (Weilheim, Germany), Alexander Bujotzek (Munich), Guy Georges (Habach, Germany) and Anja Schrade (Penzberg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for increasing the (avid-)binding specificity of a bispecific antibody comprising a first mammalian or mammalianized binding site specifically binding to a first (cell-surface) antigen and a second binding site specifically binding to a second (cell-surface) antigen, wherein the first ...