ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,561, issued on Feb. 24, was assigned to Hoffmann-La Roche Inc. (Nutley, N.J.).
"Glycosylated antibodies" was invented by Silke Hansen (Iffeldorf, Germany), Klaus-Peter Kuenkele (Benediktbeuern, Germany), Dietmar Reusch (Munich) and Ralf Schumacher (Penzberg, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/or the amount of N-terminal alpha 1,3 ga...