US Patent Issued to HOFFMANN-LA ROCHE on Feb. 17 for "Oligonucleotides for reduction of PD-L1 expression" (Danish, Swiss Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,552,862, issued on Feb. 17, was assigned to HOFFMANN-LA ROCHE INC. (Little Falls, N.J.).

"Oligonucleotides for reduction of PD-L1 expression" was invented by Lykke Pedersen (Horsholm, Denmark), Hassan Javanbakht (Basel, Switzerland), Malene Jackerott (Horsholm, Denmark), Soren Ottosen (Horsholm, Denmark) and Souphalone Luangsay (Basel, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to antisense oligonucleotides that are capable of reducing expression of PD-L1 in a target cell. The oligonucleotides hybridize to PD-L1 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutic...