US Patent Issued to Hoffmann-La Roche on Aug. 26 for "Method for producing bispecific antibodies comprising a Y436A Fc-region mutation for improved protein A-binding" (German Inventor)

ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,398,203, issued on Aug. 26, was assigned to Hoffmann-La Roche Inc..

"Method for producing bispecific antibodies comprising a Y436A Fc-region mutation for improved protein A-binding" was invented by Tilman Schlothauer (Penzberg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein the first, the second, or the first and the second polypeptide ...