US Patent Issued to Hoffmann-La Roche on April 21 for "Human FcRn-binding modified antibodies and methods of use" (German Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,606,614, issued on April 21, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Human FcRn-binding modified antibodies and methods of use" was invented by Guido Hartmann (Loerrach, Germany), Joerg Regula (Munich), Matthias Rueth (Penzberg, Germany), Wolfgang Schaefer (Mannheim, Germany) and Tilman Schlothauer (Penzberg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported the use of an antibody comprising an Fc-region with abolished FcRn binding for the transport of a soluble receptor ligand from the eye over the blood-ocular-barrier into the blood circulation."

The patent was filed on July 12, 2021, under Application N...