US Patent Issued to Heidelberg Pharma Research on March 17 for "Antibody drug conjugates with cleavable linkers" (German Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,576,158, issued on March 17, was assigned to Heidelberg Pharma Research GmbH (Ladenburg, Germany).

"Antibody drug conjugates with cleavable linkers" was invented by Christoph Mueller (Ladenburg, Germany), Werner Simon (Ladenburg, Germany), Susanne Werner-Simon (Ladenburg, Germany), Francesca Gallo (Ladenburg, Germany), Torsten Hechler (Ladenburg, Germany), Michael Kulke (Ladenburg, Germany) and Andreas Pahl (Ladenburg, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to prodrugs comprising a linker comprising five- or six-membered cyclic acetals and an adjacent specific cleavage site, and to precursor compounds for t...