US Patent Issued to GRAIL on Dec. 16 for "Identifying false positive variants using a significance model" (California Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,499,972, issued on Dec. 16, was assigned to GRAIL Inc. (Menlo Park, Calif.).

"Identifying false positive variants using a significance model" was invented by Ling Shen (Redwood City, Calif.), Catalin Barbacioru (Fremont, Calif.) and Qinwen Liu (Fremont, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A system and a method are described for applying a noise model for predicting the occurrence and a level of noise that is present in cfDNA read information. The significance model is trained for a plurality of stratifications of called variants using training data in the stratification. Stratifications may include a partition and a mutation type. The ...