US Patent Issued to GENMAB on June 30 for "Antibody variant combinations and uses thereof" (Dutch Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,668,641, issued on June 30, was assigned to GENMAB B.V. (Utrecht, Netherlands).

"Antibody variant combinations and uses thereof" was invented by Rob De Jong (Utrecht, Netherlands), Frank Beurskens (Utrecht, Netherlands), Gijs Zom (Utrecht, Netherlands), Janine Schuurman (Diemen, Netherlands) and Xiaoguang Xue (Utrecht, Netherlands).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to combination therapy involving two or more antibodies, wherein the Fc regions of the two antibodies have been modified such that hetero-oligomerization between the antibodies is strongly favored over self-oligomerization when antibodies are bound to their c...