US Patent Issued to Generation Bio on Sept. 8 for "Compositions and production of nicked closed-ended DNA vectors" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 8 -- United States Patent no. 12,729,386, issued on Sept. 8, was assigned to Generation Bio Co. (Cambridge, Mass.).

"Compositions and production of nicked closed-ended DNA vectors" was invented by Ozan Alkan (Cambridge, Mass.), Robert Michael Kotin (Cambridge, Mass.), Douglas Anthony Kerr (Cambridge, Mass.), Russell Monds (Cambridge, Mass.), Carolyn Pelletier (Cambridge, Mass.) and Matthew Stanton (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application discloses methods for synthetic production and cell-free synthesis of DNA vectors, particularly closed-ended linear DNA vectors having one or more gaps (e.g., nicked ceDNA vectors, "neDNA") and adenoassoc...