ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,644, issued on Dec. 16, was assigned to FRESENIUS KABI IPSUM S.R.L. (Milan).
"Subtilisin variants and their use" was invented by Timo Nuijens (Geleen, Netherlands), Jurgen Mateman (Geleen, Netherlands), Rowin De Visser (Geleen, Netherlands), Walter Cabri (Cassina de' Pecchi-Milano, Italy), Kerstin Wallraven (Geleen, Netherlands), Elvira Wijker (Geleen, Netherlands), Antonio Ricci (Cassina de' Pecchi-Milano, Italy) and Ana Toplak (Geleen, Netherlands).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to a subtilisin BPN' variant or homologue thereof, having new mutations compared to subtilisin BPN' represented by SEQ ID NO: 2 or a h...