ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,844, issued on March 24, was assigned to Foresee Pharmaceuticals USA Inc. (Newark, Del.).
"Matrix metalloproteinase (MMP) inhibitors and methods of use thereof" was invented by Wenjin Yang (Foster City, Calif.) and Kai-Wei Chang (Taichung City, Taiwan).
According to the abstract* released by the U.S. Patent & Trademark Office: "Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung ...