US Patent Issued to ETH ZURICH on July 28 for "Compounds and methods for amine oxidase imaging" (Swiss Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. 12,692,532, issued on July 28, was assigned to ETH ZURICH (Zurich).

"Compounds and methods for amine oxidase imaging" was invented by Matthew Ronald Aronoff (Moenchaltorf, Switzerland) and Helma Wennemers (Zurich).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention pertains to a functionalizable and enzyme-activatable fluorescent probe and methods for monitoring the activity of amine oxidases. Amine oxidases catalyze the oxidative deamination, e.g. of the Epsilon-amine of a lysine to an aldehyde which in turn can form covalent bonds with neighboring side chains, e.g. in the context of collagen cross-linking. Amine oxidase activity can be correlated...