US Patent Issued to ETH ZURICH on April 7 for "Transcriptional recording by CRISPR spacer acquisition from RNA" (Swiss Inventors)

ALEXANDRIA, Va., April 7 -- United States Patent no. 12,595,468, issued on April 7, was assigned to ETH ZURICH (Zurich).

"Transcriptional recording by CRISPR spacer acquisition from RNA" was invented by Randall Jeffrey Platt (Basel, Switzerland) and Florian Schmidt (Basel, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method for recording a transcriptome of a cell by: providing a test cell that includes a first transgene nucleic acid sequence encoding a fusion protein that is a reverse transcriptase polypeptide and a Cas1 polypeptide and a second transgene nucleic acid sequence encoding a Cas2 polypeptide, wherein the first transgene nucleic acid sequence and t...