US Patent Issued to EqIP on Nov. 3 for "Linkers for improving the stability of bioconjugates and the selectivity of payload release" (Ohio Inventors)

ALEXANDRIA, Va., Nov. 3 -- United States Patent no. 12,779,047, issued on Nov. 3, was assigned to EqIP LLC (Plain City, Ohio).

"Linkers for improving the stability of bioconjugates and the selectivity of payload release" was invented by Matthew Giese (Columbus, Ohio) and Paul Davis (Dublin, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are linker architectures for conjugates that do not rely on the SAR of the cleavable trigger or the large steric bulk of a closely positioned antibody to alter payload release. These linkers are expected to reduce off-target payload release facilitated by extracellular cathepsins, and may also be applicable to conjugates of antibody fragments that lack t...