US Patent Issued to Enzo Life Sciences on Dec. 16 for "Self-immolative probes for enzyme activity detection" (New York Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,645, issued on Dec. 16, was assigned to Enzo Life Sciences Inc. (Farmingdale, N.Y.).

"Self-immolative probes for enzyme activity detection" was invented by Irina Lebedeva (Bronx, N.Y.), Wayne Forrest Patton (Dix Hills, N.Y.), Maciej Szczepanik (Mount Sinai, N.Y.), Yuejun Xiang (Hollis Hills, N.Y.) and Praveen Pande (Holbrook, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a compound comprising the structure:(SIG)-(SI-MOD)m.In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subjec...