US Patent Issued to Emory University on March 17 for "KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto" (Georgia Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,278, issued on March 17, was assigned to Emory University (Atlanta).

"KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto" was invented by Haian Fu (Decatur, Ga.), Xiulei Mo (Snellville, Ga.) and Cong Tang (Decatur, Ga.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates to the discovery that a G12V mutant of KRAS (hereinafter KRAS G12V) binds to JAK1, i.e., the existence of a KRAS G12V and JAK1 binding interaction. In certain embodiments, this disclosure relates to methods of disrupting the KRAS G12V and JAK1 interaction reversing KRAS G12V induced immune escape by cancer cells ut...