ALEXANDRIA, Va., May 12 -- United States Patent no. 12,622,905, issued on May 12, was assigned to EISAI R&D MANAGEMENT Co. LTD. (Tokyo).

"Aryl pladienolides for the treatment of neoplastic disorders" was invented by Andrew Cook (Stow, Mass.), Dominic Reynolds (Stoneham, Mass.), Cheng Zhong (Belmont, Mass.), Ryan Brawn (Sudbury, Mass.), Shelby Ellery (Boston), Thiwanka Samarakoon (Westwood, Mass.), Xiang Liu (Winchester, Mass.), Sudeep Prajapati (Somerville, Mass.), Megan Sheehan (Allston, Mass.), Jason T. Lowe (East Bridgewater, Mass.) and James Palacino (Wellesley, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides novel pladienolide compounds according to Formula I:pharmac...