ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,272, issued on May 13, was assigned to Eianco US inc. (Greenfield, Ind.).
"IgG Fc variants for veterinary use" was invented by Hangjun Zhan (Foster City, Calif.), Lam Nguyen (Union City, Calif.), Yongzhong Li (Rockville, Md.), Fawn Qian (Burlingame, Calif.) and Shyr Jiann Li (Millbrae, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are various embodiments relating to variant IgG Fc polypeptides of companion animals having increased Protein A binding for ease of purification, decreased C1q binding for reduced complement-mediated immune responses, decreased CD16 binding (e.g., for reduced antibody-dependent cellular cytotoxicity (ADCC)...