US Patent Issued to DIOSEVE on March 3 for "Method of differentiating pluripotent or epiblast cells into immature oocytes" (Japanese Inventors)

ALEXANDRIA, Va., March 3 -- United States Patent no. 12,565,638, issued on March 3, was assigned to DIOSEVE INC. (Tokyo).

"Method of differentiating pluripotent or epiblast cells into immature oocytes" was invented by Nobuhiko Hamazaki (Tokyo) and Katsuhiko Hayashi (Fukuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for inducing immature oocytes includes introducing four genes consisting of FIGLA, NOBOX, LHX8 and TBPL2, or transcripts or expressed proteins thereof, into at least one type of cell selected from the group consisting of pluripotent stem cells, epiblast-like cells and primordial germ cells. A method for producing mature oocytes includes introducing four genes consisting of FIG...