US Patent Issued to DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS on July 28 for "Labeling of oligonucleotide probes by multiple-way ligation" (German Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. 12,692,537, issued on July 28, was assigned to DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS (Heidelberg, Germany).

"Labeling of oligonucleotide probes by multiple-way ligation" was invented by Hai-Kun Liu (Weinheim, Germany) and Yong-Sheng Cheng (Schriesheim, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a novel method for multiple labelling of nucleic acid probes by ligation. The method uses a ligase catalysed reaction to connect a nucleic acid probe with multiple pre-prepared nucleic acid label carrier molecules under the presence of a stabilizing complementary adaptor oligonucleotide. The meth...