US Patent Issued to Dana-Farber Cancer Institute on Jan. 20 for "BH4 stabilized peptides and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,528,846, issued on Jan. 20, was assigned to Dana-Farber Cancer Institute Inc. (Boston).

"BH4 stabilized peptides and uses thereof" was invented by Loren D. Walensky (Newton, Mass.), Michelle L. Stewart (Cambridge, Mass.) and Lauren Barclay (Brookline, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are polypeptides containing stabilized BH4 domains of BCL-2 family proteins that are capable of binding and/or inactivating and/or modulating BAX protein, and/or its close homologues BAK and BOK, and/or other physiological BH4 targets. Also provided are compositions containing these polypeptides and methods of treating cytotoxic diseases ...