US Patent Issued to DANA-FARBER CANCER INSTITUTE on Feb. 24 for "Sulfonamide derivatives for protein degradation" (American, Chinese Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,457, issued on Feb. 24, was assigned to DANA-FARBER CANCER INSTITUTE INC. (Boston).

"Sulfonamide derivatives for protein degradation" was invented by Nathanael S. Gray (Boston), Eric Fischer (Chestnut Hill, Mass.), Hojong Yoon (Cambridge, Mass.), Tinghu Zhang (Brookline, Mass.), Tyler Faust (Brookline, Mass.), Katherine Donovan (Boston), Quan Cai (Shanghai) and Zhengnian Li (Newton, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "DCAF15 is a substrate recognition (adaptor) protein of E3 ubiquitin ligase. Disclosed herein are compounds that recruit ubiquitin ligase CRL4DCAF15, to a target RNA recognition motif (RRM), causing its degradation. Als...