US Patent Issued to Dana-Farber Cancer Institute, The General Hospital on May 12 for "Compounds for tau protein degradation" (American, Chinese Inventors)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,622,901, issued on May 12, was assigned to Dana-Farber Cancer Institute Inc. (Boston) and The General Hospital Corp. (Boston).

"Compounds for tau protein degradation" was invented by Nathanael S. Gray (Boston), Stephen J. Haggarty (Gloucester, Mass.), Quan Cai (Shanghai), Tinghu Zhang (Brookline, Mass.), Maria Catarina Telo Baptista Lima da Silva (Revere, Mass.) and Fleur M. Ferguson (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are bifunctional compounds that bind tau protein and/or promote targeted ubiquitination for the degradation of tau protein. In particular, provided are compounds that can bind tau protein, a pro...