ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,685, issued on Feb. 10, was assigned to Daiichi Sankyo Co. Ltd. (Tokyo).
"Dispiropyrrolidine derivatives" was invented by Yuuichi Sugimoto (Tokyo), Kouichi Uoto (Tokyo), Takanori Wakabayashi (Tokyo), Masaki Miyazaki (Tokyo), Masaki Setoguchi (Tokyo), Toru Taniguchi (Tokyo), Keisuke Yoshida (Tokyo), Akitake Yamaguchi (Tokyo) and Shoko Yoshida (Tokyo).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, an...