US Patent Issued to CZ Biohub SF, The Board of Trustees of the Leland Stanford Junior University on March 31 for "Directed evolution for obtaining improved variants of TEV protease for biotechnological applications" (California Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,325, issued on March 31, was assigned to CZ Biohub SF LLC (San Francisco) and The Board of Trustees of the Leland Stanford Junior University (Stanford, Calif.).

"Directed evolution for obtaining improved variants of TEV protease for biotechnological applications" was invented by Alice Y. Ting (Palo Alto, Calif.) and Mateo Isidro Sanchez Lopez (Menlo Park, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Tobacco etch virus protease (TEV) is one of the most widely used proteases in biotechnology because of its exquisite sequence-specificity. A limitation of TEV is its slow catalytic rate, which limits product generation and therefore signal outp...