US Patent Issued to CYTOMX THERAPEUTICS on March 31 for "Protease-cleavable substrates and methods of use thereof" (California, Colorado Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,589,164, issued on March 31, was assigned to CYTOMX THERAPEUTICS INC. (South San Francisco, Calif.).

"Protease-cleavable substrates and methods of use thereof" was invented by Olga Vasiljeva (Highlands Ranch, Colo.) and Michael B. Winter (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "Isolated polypeptides that include a cleavable moiety that is a substrate for at least two proteases (e.g., MT-SP1 and an MMP) are disclosed. Activatable molecules including the isolated polypeptides are disclosed. Methods of making and using the isolated polypeptides and activatable molecules including the isolated polypeptides in a variety of therapeutic, ...