ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,460,204, issued on Nov. 4, was assigned to CureVac SE (Tubingen, Germany).
"Artificial nucleic acid molecules for improved protein or peptide expression" was invented by Andreas Thess (Kusterdingen, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to an artificial nucleic acid molecule comprising at least one 5' UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and/or a 3' UTR. The invention further relates to the use of such an artif...