ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,528,850, issued on Jan. 20, was assigned to Cue Biopharma Inc. (Boston).
"TGF-Beta polypeptides" was invented by Ronald D. Seidel III (Natick, Mass.), Rodolfo J. Chaparro (Cambridge, Mass.), John F. Ross (Arlington, Mass.) and Chee Meng Low (Cambridge, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides T-cell modulatory multimeric polypeptides (T-Cell-MMP) and their epitope conjugates comprising at least one immunomodulatory polypeptide ("MOD") that may be selected to exhibit reduced binding affinity to a cognate co-immunomodulatory polypeptide ("Co-MOD"). The epitope may be, for example, a cancer-associated epitope, an...