US Patent Issued to CITY OF HOPE on June 2 for "Hinge-modified IgG antibody compositions for protease resistance and fc-Gamma receptor binding and methods of making the same" (California Inventors)

ALEXANDRIA, Va., June 2 -- United States Patent no. 12,643,942, issued on June 2, was assigned to CITY OF HOPE (Duarte, Calif.).

"Hinge-modified IgG antibody compositions for protease resistance and fc-Gamma receptor binding and methods of making the same" was invented by Michael A. Caligiuri (Pasadena, Calif.), Hongsheng Dai (Monrovia, Calif.) and Tongwen Zhang (Monrovia, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are antibodies, recombinant proteins, and methods of use thereof including, for example, immunoglobulin G (IgG) antibodies and recombinant proteins including a Fab region and an Fc region connected through a hinge region, where the hinge region is resistant to cleavage b...