US Patent Issued to CHUGAI SEIYAKU on Oct. 27 for "Immunoactivating antigen-binding molecule" (Japanese Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,345, issued on Oct. 27, was assigned to CHUGAI SEIYAKU K.K. (Tokyo).

"Immunoactivating antigen-binding molecule" was invented by Tomoyuki Igawa (Shizuoka, Japan), Taro Miyazaki (Kanagawa, Japan), Kenji Taniguchi (Kanagawa, Japan) and Naoka Hironiwa (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of canc...