US Patent Issued to Chugai Seiyaku on Jan. 13 for "Antigen-binding molecule containing modified Fc region" (Japanese Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,648, issued on Jan. 13, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Antigen-binding molecule containing modified Fc region" was invented by Tomoyuki Igawa (Shizuoka, Japan), Naoka Hironiwa (Shizuoka, Japan), Shojiro Kadono (Kanagawa, Japan), Atsushi Matsuo (Shizuoka, Japan), Taichi Kuramochi (Shizuoka, Japan) and Futa Mimoto (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present inventors have successfully prepared an antibody Fc region dimer that has binding activity against each of an antigen and FcGammaR, but does not bind to the antigen and the FcGammaR at the same time, and a polypeptide comprising the Fc region dimer. Th...