US Patent Issued to Chugai Seiyaku on Feb. 10 for "Bispecific antibody exhibiting increased alternative FVIII-cofactor-function activity" (Japanese Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,743, issued on Feb. 10, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Bispecific antibody exhibiting increased alternative FVIII-cofactor-function activity" was invented by Tomoyuki Igawa (Shizuoka, Japan), Yuri Teranishi (Shizuoka, Japan), Kazuki Kato (Shizuoka, Japan) and Hikaru Koga (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides light chain amino acid substitutions that improve the FVIII cofactor function-substituting activity of ACE910 (Emicizumab), novel light chains showing FVIII cofactor function-substituting activity, and heavy chain amino acid substitutions that improve the FVIII cofactor func...