ALEXANDRIA, Va., April 7 -- United States Patent no. 12,595,299, issued on April 7, was assigned to Chugai Seiyaku K.K. (Tokyo).
"FC variants" was invented by Tomoyuki Igawa (Shizuoka, Japan), Atsuhiko Maeda (Shizuoka, Japan), Kenta Haraya (Shizuoka, Japan), Tatsuhiko Tachibana (Shizuoka, Japan) and Yuki Iwayanagi (Shizuoka, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8...