US Patent Issued to Children's Medical Center on June 30 for "Compositions and methods for gene replacement" (Massachusetts Inventor)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,667,628, issued on June 30, was assigned to Children's Medical Center Corp. (Boston).

"Compositions and methods for gene replacement" was invented by Jeffrey R. Holt (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention features a dual vector system for disrupting and replacing a target gene comprising a mutation (e.g., dominant, recessive mutation). Embodiments of the invention may also provide compositions comprising the dual vector system, and methods of using the dual vector system, including but not limited to methods of modifying the genome of a cell, methods of genomic editing, and methods of treating cells or a subject suf...