ALEXANDRIA, Va., May 26 -- United States Patent no. 12,637,665, issued on May 26, was assigned to Cevec Pharmaceuticals GmbH (Cologne, Germany).
"Method for the production of AAV" was invented by Juliana Coronel (Cologne, Germany) and Silke Wissing (Marburg, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to methods for the production of Adeno-associated virus (AAV), comprising steps of providing a stable AAV producer cell line in which at least some or all genes encoding the components necessary for the production of AAV are stably integrated into the cell genome, and culturing said cells in perfusion culture during the AAV production step (i.e., during the N step), wher...